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. Author manuscript; available in PMC: 2021 Sep 9.
Published in final edited form as: Neuron. 2020 Jul 17;107(5):891–908.e8. doi: 10.1016/j.neuron.2020.06.021

Figure 6. Mitochondrial oxidative phosphorylation pathway mRNAs are downregulated in SPNs of the R6/2 and zQ75DN models, as well as SPNs of HD tissue.

Figure 6.

A. Schematic of the OXPHOS component complexes, with log2-fold change heat maps depicting altered expression of OXPHOS component mRNAs in dSPNs or iSPNs of the R6/2 model at 9-weeks of age or the zQ175DN model (compared to the Q20 control) at 6-months of age. B. OXPHOS Complex I activity measurement from whole R6/2 tissue at 9-weeks of age (top panel: striatum; bottom panel: hippocampus control). C. Heatmaps depicting altered expression of OXPHOS component mRNAs in dSPNs or iSPNs of human HD tissue.