Fig. 2.

Tibias from old mice had less transcriptional induction after loading compared to young-adult mice. (A) Old mice had fewer upregulated and downregulated DEGs at every time point. (B) Old mice had lower fold-change inductions of the shared upregulated DEGs at day 3 and day 5 (*p < .0001, Wilcoxon matched-pairs test). (C) Old and young-adult mice shared a similar proportion of DEGs across days of loading. (D) Old and young-adult mice shared more upregulated DEGs than downregulated DEGs. At day 3 and day 5, 33% and 39% of upregulated DEGs were shared, respectively, whereas only 3% and 4% of downregulated DEGs were shared. DEG = differentially expressed gene.