Table 1.

Top 10 Genes by FC for Each Day

Young-adult
	Day 1		Day 3		Day 5
	Gene	FC	Gene	FC	Gene	FC
Upregulated	Wnt7b	7.78	Serpina3m	19.24	Bcan	24.93
	Gm42679	5.75	Serpina3n	11.83	HapIn4	22.01
	Wnt1	5.75	CcI7	9.75	Car12	19.17
	Ngf	4.74	Rrad	8.04	Nell1	13.91
	Ighv7-1	3.98	Wnt1	6.70	BCO21891	11.42
	Ddn	3.96	Strati	6.49	Rrad	10.73
	Gm15564	3.64	Wnt7b	6.37	Serpina3n	10.71
	Igkv15-103	3.15	Ddn	6.13	Fam84a	10.57
	Fosb	3.04	Card14	6.06	Slc13a5	9.22
	Ptgs2	2.98	CcI2	5.77	Slc6a2	8.61
Downregulated	Col9a1	0.15	Fgf23	0.20	Perm1	0.10
	CytI1	0.35	Csrp3	0.30	Smco1	0.12
	Col9a2	0.36	Igkv3-4	0.33	Cyp2e1	0.12
	Col9a3	0.37	Ighv11-2	0.35	Gm8424	0.13
	Igkv8-27	0.37	Igkv5-39	0.35	Csrp3	0.13
	C1qtnf3	0.38	Actc1	0.38	Dhrs7c	0.13
	Slc6a1	0.43	Pamr1	0.39	Ckmt2	0.14
	Ighv11-2	0.47	Igkv14-126	0.40	Fgf23	0.15
	Hapln1	0.47	Prdm8	0.40	Scg3	0.15
	Ighv4-1	0.48	Perm1	0.41	9430073C21Rik	0.16

Old
	Day 1		Day 3		Day 5
	Gene	FC	Gene	FC	Gene	FC
Upregulated	Ngf	1.50	HapIn4	2.64	Prss35	3.69
	Rrad	1.48	Slc6a2	2.48	Bglap	3.40
	Gm42679	1.44	Cthrcl	2.45	Slc13a5	3.32
	Wnt7b	1.44	Fkbp11	2.36	Col11a1	3.29
	Ddn	1.41	II11	2.34	Cthrcl	3.20
	Wnt1	1.39	Wnt1	2.33	Col1a1	2.95
	Dusp6	1.36	Gm10629	2.30	Bglap2	2.89
	Gem	1.35	Ddn	2.28	Smpd3	2.88
	Ptgs2	1.32	Tubb3	2.25	Bcan	2.88
	Akr1 b8	1.30	Lurap1I	2.24	Cgrefl	2.86
Downregulated	Tigit	0.74	Gm28653	0.45	Mpz	0.45
	Tox2	0.74	Abra	0.48	Hepacam2	0.50
	1110001J03Rik	0.76	Gbp10	0.51	Cldn19	0.52
	Gm10451	0.76	Atp1b4	0.52	Ncmap	0.52
	Mcee	0.77	2310020H05Rik	0.52	Mal	0.53
	Phpt1	0.77	Islr2	0.53	Igkj5	0.55
	Gm26613	0.77	Fgf23	0.53	Ly6d	0.55
	Igkv5-48	0.78	Klf15	0.55	Gm15675	0.56
	RP23-385F8.1	0.78	Snai3	0.55	Gjc3	0.56
	Gm43618	0.80	Gm8424	0.55	Ugt8a	0.56

Bold denotes DEG (FC>1.5 or <0.67 & FDR <0.05)