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Biochemical characterization of DC431 and DC432. (A,B) IC50 curve of DC431 and DC432. IC50 values were determined in triplicates (n = 3) and presented as mean ± SD. (C) Representative western blots showing N-terminal dimethylation (Me2RCC1) and trimethylation (Me3RCC1) of full-length recombinant human RCC1 by full-length recombinant human NTMT1 in the presence of increasing concentrations of BM30, DC431 and DC432 (n=3). NTMT1 and RCC1 blots are shown as loading controls.
