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. 2020 Sep 12;886:173548. doi: 10.1016/j.ejphar.2020.173548

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Fig. 3 — Renin-Angiotensin System (RAS) and SARS-Cov-2. In classis RAS system, ACE convert angiotensin I to angiotensin II. Angiotensin II is converted to Angiotensin 1-7 by ACE-2. SARS-Cov-2 binds with ACE-2 on the cell surface and internalizes via endocytosis carrying ACE-2 along, thereby essentially decreases ACE-2 availability. Decreases availability in ACE-2 strikes imbalance between Angiotensin-II and Angiotensin 1-7. ACE inhibitors or Angiotensin receptor blockers may have value in reversing the imbalance (Adapted from (Guo et al., 2020)).