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. 2020 Sep 11;10:14977. doi: 10.1038/s41598-020-71939-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sampling locations and general overview of the faecal and biopsy-derived metagenomic datasets. (A) For each of the 5 enrolled subjects, gut mucosa biopsies were collected from terminal ileum (TI), transverse colon (TC), and rectum (RE); in one subject, as it was not possible to reach her TI, one biopsy was taken from the adjacent caecum instead (CA). Faeces (FE) were also sampled. (B, C) PCoA plots of the downsized biopsy-faeces dataset (B), colour-coded by sampling-location, and of biopsies data only (C), colour-coded by subject. The only caecal sample of this study is indicated by an asterisk. (D, E) Percentage of shared metagenomic species (in dark red) between biopsy location pairs (D), and between biopsy locations and FE (E).