Fig. 9.

Histological analysis of host response to the Gastrodin/PU films following 2-week subcutaneous implantation. Retrieved tissue samples (A–D) and Masson's Trichrome-stained histological sections (E–L) of PU (A, E, I), 1Gastrodin/PU (B, F, J), 2Gastrodin/PU (C, G, K) and 5Gastrodin/PU (D, H, L). (M) Analysis of the thickness of fibrotic capsules surrounding the implants. (N) Representative high magnification images of the stained 2Gastrodin/PU sample. “F” denotes films and the dashed lines mark the tissue-material implant interface. Arrows indicate blood vessels; two-way red arrows mark the span of the fibrotic capsule at the film-tissue interface. (Error bars represent standard deviation from the mean (n = 3). ***p < 0.001, **p < 0.01; *p < 0.05; ns: no significant difference.).