Fig. 5.

Fabrication of neutrophil-mimicking nanoparticle (NM-NP), assessment of pre-metastatic niche targeting, and application in lung metastasis therapy. (A) NM-NP for targeting CTCs and pre-metastatic niche. (B) Targeting property of NM-NP compared with naked nanoparticle in the pre-metastatic region as displayed by confocal microscopy. Scale bar: 50 µm. (C) Quantification of metastasis nodules in lung tissue slides of different groups. (D) S100A9 positive neutrophil level in different treating groups. Reproduced with permission from [103]. Copyright 2017 American Chemical Society.