Fig. 8.

ROS responsive drug DDSs. (A) ROS generation based on photodynamic therapy: the construction of Pros-PDC NPs with prolonged circulation time and enhanced cellular internalization, and light-triggered ROS generation and the newly generated ROS activated anticancer drug release of the DOX and IR780 co-loaded Pros-PDC NPs with a spatially and temporally precise profile, adapted from reference (Reproduced with permission from [120]. Copyright 2017 Elsevier). (B) ROS generation based on ROS producing agent administration: structure of T/D@RSMSNs nano-system and its positive feedback mechanism for ROS-responsive self-accelerating drug release (Reproduced with permission from [127]. Copyright 2017 Elsevier). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)