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. 2019 Sep 26;15(4):416–448. doi: 10.1016/j.ajps.2019.08.003

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© 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig 13 — Schematic design of smart nanocarriers coated with pH-/thermal-/GSH-responsive polymer zippers for precision anticancer molecular drug delivery (Reproduced with permission from [201]. Copyright 2017 WILEY-VCH). (A) NIR-/pH-guided cellular uptake and GSH/HAase-controlled release in vivo. (i) Passive accumulation at tumor sites in the PEG state via the EPR effect; (ii) NIR-/pH-activated surface shift to the Gu⁺/CPD-SS-RGD state with positive charge and RGD ligand for selective uptake; (iii) Endosome escape and controlled release by endogenous GSH/HAase; (iv) nonspecific retention and clearance in normal tissues. (B) The surface state variations during drug delivery (the polymer zipper decoding and the sandwich protective shell degradation). (C) The composition of the Gu⁺/CPD-SS-RGD and PY⁻/PTP-PEG polymer zipper with multiple pY⁻/Gu⁺ salt bridges. The Gu⁺/CPD-SS-RGD was prepared with a cyclic peptide with a sequence of arginine-glycine-aspartic acid (RGD) as an initiator. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)