. 2020 Sep 7;15:37–46. doi: 10.1016/j.tipsro.2019.11.005

Table 1.

PSPT and IMPT dosimetric end-points in identified studies.

Authors/Year	Dose prescription (RBE)	Difference in OAR doses (PSPT-IMPT)							Result presented/test
		Lung			Heart	Oesophagus	Cord
		Combined	Ipsilateral	Contra-lateral	Heart	Oesophagus	Cord
Georg et al. (2008) [18]	45 Gy, 3#, 65% isodose	N/A	D_mean: 0.2 Gy V_2Gy: 3.2% V_4Gy: 3.3% V_6Gy: 3% V_12Gy: 1.2%	N/A	D_1%: 0.2 Gy V_2Gy: 0.3 cc V_4Gy: −0.1 cc	D_1%: −0.2 Gy	N/A	DIBH	Mean Statistical significance not tested
Georg et al. (2008) [18]	45 Gy, 3#, 65% isodose	N/A	D_mean: 0.4% V_2Gy: 3.5% V_4Gy: 3.6% V_6Gy: 2.9% V_12Gy: −1.7%	N/A	D_1%: −0.2 Gy V_2Gy: 0.2 cc V_4Gy: −0.1 cc	D_1%: −0.2 Gy	N/A	SB + AC	Mean Statistical significance not tested
Zhang et al. (2010) [21]	74 Gy, NA	V_5Gy: 5.3% V_10Gy:5.3% V_20Gy: 4.0% V_30Gy: 3.3% D_mean: 2.7 Gy	V_5Gy: 6.2% V_10Gy:7.3% V_20Gy: 6.9% V_30Gy: 5.4% D_mean: 4.3 Gy	V_5Gy: 4.3% V_10Gy:3.0% V_20Gy: 1.0% V_30Gy: 1.0% D_mean: 1.0 Gy	V_40Gy: 0.8%	V_40Gy: 2.6% V_55Gy: 2.3%	D_max: −1.7 Gy D_1%: 1.7 Gy		Median Statistical significance not tested
Register et al. (2011) [19]	50 Gy, 4#, 100% isodose	V_5Gy: 1.4%^* V_10Gy:2.1%^* V_20Gy: 1.2%^* D_mean: 0.7 Gy^*	N/A	N/A	D_max: 1.9Gy^ns	D_max: 10.2 Gy^*	D_max: 4.8 Gy^**		Mean Paired t-test
Berman et al. (2013) [16]	50.4 Gy, 28#, 95% isodose	V_5Gy: 8.7%^* V_10Gy:9.7%^* V_20Gy: 8.2%^* V_30Gy: 5.9%^* D_mean: 3.4 Gy^***	V_5Gy: 8.4%^ V_10Gy:11.1%^* V_20Gy: 11.7%^* V_30Gy: 10.2%^* D_mean: 4.8 Gy^***	V_5Gy: 8.6%^* V_10Gy:8.7%^* V_20Gy: 6.1%^ V_30Gy: 3.3%^* D_mean: 2.5 Gy^***	V_40Gy: 5.6%^* D_mean: 3.7 Gy^*	V_40Gy: 5.0%^n/a D_mean: 2.2Gy^n/a	D_max: 20.8 Gy^*** D_1%: 16.0Gy^n/a		Mean Paired t-test
Chang et al. (2014) [17]	D_median = 66 Gy (45–78)	V_5Gy: 1.2%^ns V_20Gy: 4.4%^* D_mean: 2.4 Gy^*	N/A	N/A	V_40Gy: 2.1%^ns	V_60Gy: 11.1%^*	N/A		Mean Paired t-test Values were digitised from graph.
Lin et al. (2015) [24]	66.6 Gy in 18#, 99% isodose	V_5Gy: 4.3%^ V_20Gy: 4.5%^* D_mean: 2.3 Gy^***	N/A	N/A	V_30Gy: 2.3%^** V_45Gy: 2.0%^ns D_max: 4.5 Gy^*	D_max: 3.7 Gy^*	D_max: 5.3 Gy^*		Mean Paired t-test
Zeng et al. (2016) [20]	30.6 Gy in 17#, 97% isodose	V_5Gy: 5.0%^* V_10Gy:5.0%^* V_20Gy: 6.0%^* V_30Gy: 4.0%^* D_mean: 2 Gy^*	N/A	N/A	V_5Gy: 2.0%^ns V_10Gy: 2.0%^* V_20Gy: 4.0%^* V_30Gy: 8.0%^* D_max: 2.0 Gy^* D_mean: 1.3 Gy^*	N/A	D_max: 10 Gy^*		Median Wilcoxon signed rank test

Abbreviations: IMPT = intensity modulated proton therapy; PSPT = passive-scattered proton therapy; RBE = Radiobiological Effectiveness, OAR = organ-at-risk; DIBH = deep inspiration breath-hold; SB + AC = shallow breathing and abdominal compression; N/A = Not available; V_xGy = volume of OAR receiving × Gy; D_mean = mean dose; D_max = max dose; D_median = median dose; D_x% = Dose to x% volume of OAR.

p ≤ 0.05.

^**

p ≤ 0.01.

^***

p ≤ 0.001.

^ns

p > 0.05.

^n/a

p-value not reported.