Skip to main content
. 2020 Sep 7;15:37–46. doi: 10.1016/j.tipsro.2019.11.005

Table 4.

Comparison of studies that reported on interplay management.

Authors/Year Participants
IMPT Parameters
n Indications Median Motion Amplitude (mm) Treatment Volume (cm3) Robust Optimisation Spot Size (mm) Rescanning
Liu et al. (2016) [29] 11 Stage II (1), III (9), IV (1) NSCLC 5.0 (2.0–15) CTVmedian = 484.9 (103.8–1248.0) 4D and 3D robust optimisation 6–14 N/A
Jakobi et al. (2018) [28] 40* Patients receiving SBRT to the lung <5 mm:
1.6 (0.6–4.5)
>5 mm:
10.2 (5.7–23.3)
GTVmedian = 9.0 (0.3–37.0) N/A 3–8 N/A
Engwall et al. (2018) [27] 3 N/A 6.0 (3.7–12.2) CTVmean = 44.3 (6.5–73.7) 4D robust optimisation with and without time structures N/A Layer
Grassberger et al. (2013) [31] 10 N/A 10.3 (2.9–30.6) GTVmedian = 23.1 (2.6–82.3) N/A Small spot:
2–3
Big spot:
11–15
N/A
Liu et al. (2018) [30] 10 Stage II (1), III (8), IV (1) NSCLC 5.0 (2.0–15) ITVmedian = 553.2 (124.3–1314.0) 3D voxel-wise worst-case robust optimisation Small spot:
2–6
Big spot:
5–15
Isolayered
Dowdell et al. (2013) [10] 5 N/A 15.1 (2.9–30.6) CTV50 = 83.3 (50.4–167.1) N/A Small spot:
2–4
Big spot:
9–16
N/A
Kraus et al. (2011) [36] 2 N/A 10.3 (9.5–11) CTV = 108.5 (82.2–134.8) N/A N/A Volumetric
Kardar et al. (2014) [35] 7 Stage III NSCLC 4.6 (1.4–16.6) GTV = 236.8 (20.6–545.1) 3D worst-case robust optimisation 5.4–14.6 Isolayered
Inoue et al. (2016) [34] 10 Stage III NSCLC 3.5 (1.4–6.6) iCTVmedian = 152.4 (21.8–428.2) Minimax robust optimisation 3 Layer
Grassberger et al. (2015) [33] 5 N/A 10.7 (2.9–30.6) GTVmedian = 26.0 (21.1–82.3) N/A Small spot:
2–4
Big spot:
8–17
Varied
Engwall et al. (2018) [32] 7 N/A 6 (3.7–12.2) CTVmean = 52.5 (6.5–176.8) 4D robust optimisation 2.5–6.8 Varied
Li et al. (2015) [38] 10 Stage II, III NSCLC 8.5 (5–17) CTVmedian = 222.85 (158.9–539.6) N/A 5.6–14.9 N/A
Li et al. (2014) [37] 11 Stage III NSCLC 4.3 (1.4–16.6) CTVmedian = 370.4 (26.2–1119.8) N/A 5.4–14.6 Isolayered
Kanehira et al. (2017) [15] 7 Stage I NSCLC SI: 11 (5.8–24.7) GTVmedian = 3.5 (2.0–14.4) N/A N/A N/A

Abbreviations: n = number of study participants; NSCLC = non-small cell lung cancer; CTV = clinical target volume; N/A = not available; SBRT = stereotactic body radiation therapy; GTV = gross tumour volume; ITV = internal target volume; CTV50 = clinical target volume at phase 50 of 4D scan; iCTV = internal clinical target volume; SI = superior inferior.

*

Only 30 participants were used for comparison in study.