Table 1.
Enriched pathway analysis and their functional categories
| Functional Categories | Pathway | Regulator Gene Name in Pathway | p-Value | Log Fold change |
|---|---|---|---|---|
| Signaling Transduction | TGF-beta signaling pathway | BAMBI | 8.90E-19 | 5.2684 |
| SMAD7 | 5.91E-06 | 1.6536 | ||
| INHBA | 1.52E-21 | 2.327 | ||
| CDKN2B | 2.19E-14 | 1.74 | ||
| PITX2 | 1.38E-41 | 3.5955 | ||
| WNT signaling pathway | CCND1 | 3.80E-08 | 1.2589 | |
| GPC4 | 1.36E-42 | 4.3748 | ||
| BAMBI | 8.90E-19 | 5.2684 | ||
| NFATC4 | 1.31E-10 | -1.3164 | ||
| SFRP4 | 1.49E-07 | -8.1966 | ||
| DKK1 | 3.20E-09 | 2.8133 | ||
| SFRP2 | 9.50E-27 | -7.8593 | ||
| TCF7L1 | 2.43E-05 | 2.3311 | ||
| DKK2 | 1.88E-08 | 2.1996 | ||
| FZD1 | 5.61E-17 | -2.3299 | ||
| LRP5 | 8.96E-11 | 1.7443 | ||
| TCF7L2 | 0.0030771 | 1.5690 | ||
| Celllular Communication | mTOR Signalling Pathway | VEGFA | 2.66E-10 | 1.0362 |
| PI3K/Akt Signalling Pathway | ITGA3 | 4.61E-14 | 2.9903 | |
| TNC | 1.03E-19 | -1.4597 | ||
| NGFR | 0.00023885 | -7.0205 | ||
| COL5A3 | 6.86E-14 | -1.3267 | ||
| LAMB1 | 1.63E-36 | 1.0533 | ||
| FLT1 | 1.53E-42 | 8.3424 | ||
| COMP | 7.50E-61 | -2.7148 | ||
| VTN | 5.31E-09 | 7.2324 | ||
| CCND1 | 3.80E-08 | 1.2589 | ||
| VEGFA | 2.66E-10 | 1.0362 | ||
| LAMA4 | 1.06E-07 | -1.3721 | ||
| SGK1 | 1.10E-05 | 1.5521 | ||
| LAMA5 | 6.14E-06 | 3.2191 | ||
| COL4A2 | 2.41E-266 | 4.4393 | ||
| EPHA2 | 4.58E-16 | 2.5843 | ||
| OSMR | 1.47E-05 | 1.0598 | ||
| ITGB1 | 1.76E-53 | 1.1654 | ||
| VEGFB | 5.22E-08 | -1.0511 | ||
| THBS2 | 1.95E-63 | 1.092 | ||
| COL4A1 | 8.24E-208 | 5.2997 | ||
| COL4A5 | 2.06E-08 | 3.5296 | ||
| ITGA1 | 1.76E-12 | 3.1042 | ||
| P53 signalling pathway | CCND1 | 3.80E-08 | 1.2589 | |
| CD82 | 3.94E-05 | 1.1701 | ||
| SERPINE1 | 8.52E-299 | 2.1331 | ||
| STEAP3 | 9.73E-08 | -1.7067 | ||
| TP53I3 | 3.91E-07 | -1.2232 | ||
| CCNG2 | 0.00017411 | 1.2924 | ||
| IGFBP3 | 1.62E-168 | -2.411 |