Table 2.
Comparison of clinical manifestations, laboratory and radiologic findings in hospitalized elderly CAP patients with clinical failure and clinical success (n = 3011)
| Characteristics | CF(n = 395) | CS(n = 2616) | p value |
|---|---|---|---|
| Clinical features | |||
| Fever | 208 (52.7) | 1364 (52.1) | 0.871 |
| Cough | 327 (82.8) | 2368 (90.5) | <0.001 |
| Chest pain | 20 (5.1) | 244 (9.3) | 0.004 |
| Wheezing | 214 (54.2) | 1034 (39.5) | <0.001 |
| Cyanosis | 89 (22.5) | 292 (11.2) | <0.001 |
| Lower extremity edema | 98 (24.8) | 366 (14.0) | <0.001 |
| Mental confusion | 2016 (26.8) | 137 (5.2) | <0.001 |
| RR > 24beats/min | 62 (15.7) | 119 (4.5) | <0.001 |
| HR > 125beats/min | 34 (8.6) | 40 (1.5) | <0.001 |
| Hypotension | 92 (23.3) | 386 (14.8) | <0.001 |
| Laboratory findings | |||
| WBC > 10,000/mm3(n = 2944) | 172 (45.1) | 762 (29.7) | <0.001 |
| The rate of NE(n = 2917) | 0.8 ± 0.2 | 0.7 ± 0.1 | <0.001 |
| The rate of L(n = 2890) | 0.1 ± 0.1 | 0.2 ± 0.6 | 0.007 |
| NE/L(n = 2889) | 14.3 ± 16.5 | 7.1 ± 9.4 | <0.001 |
| HCT<30%(n = 2874) | 86 (22.9) | 310 (12.4) | <0.001 |
| Cr > 123.76 umol/L (n = 2878) | 68 (18.2) | 217 (8.7) | <0.001 |
| Glucose> 14 mmol/L(n = 2757) | 19 (5.5) | 68 (2.8) | 0.013 |
| Na<130 mmol/L(n = 2890) | 55 (14.7) | 141 (5.6) | <0.001 |
| BUN> 7 mmol/L(n = 2887) | 202 (53.6) | 689 (27.5) | <0.001 |
| PH<7.3(n = 1884) | 24 (7.7) | 21 (1.3) | <0.001 |
| PaO2/FiO2<200 mmHg(n = 1857) | 70 (23.0) | 138 (5.9) | <0.001 |
| Albumin<25 g/L(n = 2863) | 57 (15.7) | 154 (6.2) | <0.001 |
| Complications | |||
| Respiratory failure | 329 (83.3) | 196 (7.5) | <0.001 |
| Arrhythmia | 60 (15.2) | 45 (1.7) | <0.001 |
| Acute heart failure | 151 (38.2) | 199 (7.6) | <0.001 |
| Acute myocardial infarction | 24 (6.1) | 9 (0.3) | <0.001 |
| Acute liver failure | 27 (6.8) | 17 (0.6) | <0.001 |
| Acute renal failure | 63 (15.9) | 14 (0.5) | <0.001 |
| Stroke | 17 (4.3) | 15 (0.6) | <0.001 |
| DIC | 4 (1.0) | 1 (0) | 0.001 |
| Gastrointestinal bleeding | 47 (11.9) | 21 (0.8) | <0.001 |
| Thromboembolic disease | 4 (1.0) | 13 (0.5) | 0.266 |
| Radiology findings on CT | |||
| Multilobe infiltration (n = 3011) | 193 (48.9) | 1181 (45.1) | 0.178 |
| Pleural effusion (n = 3011) | 146 (37.0) | 603 (23.1) | <0.001 |
Abbreviations: RR Respiratory rate; HR Heart rate; WBC White blood cell; NE Neutrophil; L Lymphocyte; HCT Hematocrit; Cr Creatinine; Na Sodium; BUN Blood urea nitrogen; PaO2/FiO2, Partial arterial oxygen pressure/fraction of inspired oxygen; DIC Disseminated intravascular coagulation; CT Computed tomography