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. 2020 Aug 19;40(34):6649–6659. doi: 10.1523/JNEUROSCI.0189-20.2020

Figure 1.

Figure 1.

Experimental timeline. M83+/− mice were differentiated into α-syn and control groups via intramuscular injection of either α-syn fibrils or PBS, respectively. In vivo dMRI, sensory-evoked fMRI, and resting-state fMRI were collected pre-injection, four weeks post-injection, and 12 weeks post-injection on all mice. A heat stimulation of 42°C was performed on the hind paw in a block paradigm during sensory-evoked fMRI. Rotarod locomotor assessments were performed in the week preceding imaging.