Fig. 3.
Brain-wide white matter changes in PLP mice show significant differences that are rescued by L-NAME treatment. (A) Voxel-based statistical parametric T map demonstrating reliable differences between Plp-Nf1fl/+ (n = 10) and control (n = 11) mice before L-NAME treatment in multiple white matter structures. bsc, brachium of superior colliculus; fr, fasciculus retroflexus; int, internal capsule; IIn, optic nerve; ml, medial lemniscus; pc, posterior commissure. (B) Response of selected brain structures to pharmacologic inhibition of NOS (by L-NAME treatment) in both genotypes. #P < 0.1; *P < 0.05; **P < 0.01, Wilcoxon signed-rank test.