Fig. 4.

Reduced brain-wide connectivity in the motor network is rescued by L-NAME treatment. (A) Group average correlation maps demonstrate reduced interhemispheric connectivity between control (Top) and Plp-Nf1^fl/+ (Bottom) mice. Z(r), Fisher’s Z- transformed r; MOp, primary motor cortex; SSp, primary somatosensory cortex. (B) Correlation of seed-to-seed analysis in the primary motor cortex (denoted as a plus sign in the maps shown in A), plotted for each group before and after L-NAME treatment, demonstrating reduced connectivity between control and Plp-Nf1^fl/+ that is rescued by inhibition of NOS. (C) FA in the corpus callosum is plotted as a function of interhemispheric functional connectivity of the motor cortex. The dashed lines represent linear fit for control (blue) and Plp-Nf1^fl/+ (red). (D) Structural and functional change due to treatment are plotted. FA change ratio defined as $\frac{{\text{FA}}_{\text{after}}}{{\text{FA}}_{\text{before}}}$ and functional connectivity Z(r) change ratio defined as $\frac{\text{Z}{\left(\text{r}\right)}_{\text{after}}}{\text{Z}{\left(\text{r}\right)}_{\text{before}}}$ are plotted. Dashed lines represent linear fit for control and Plp-Nf1^fl/+.