Fig. 3.

ELOVL1 or SLC27A1 knockdowns promote accumulation of specific lipid molecules. (A) Heat map representation and 2D clustering (Euclidean distance and complete-linkage clustering) of the Z-scores of all lipid species identified in the lipidomic analysis of differentiation-inducing knockdowns and control keratinocytes. (B) Sample variation along the first two principal components. (C and D) Sample separation along the first two components by sPLS of the 48 h (C) and 72 h (D) samples. (E and F) Contribution of the 50 most discriminant lipid species to the separation along the first and second components of sPLS for the 48 h (E) and 72 h (F) samples.