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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: Lab Chip. 2019 Mar 27;19(7):1193–1204. doi: 10.1039/c8lc00755a

Figure 6. The PDAC TMES responds to drugs at human patient doses.

Figure 6.

(A) Cells were grown in the TMES for four days and then dosed for 3 days with 5.31 uM gemcitabine, the dose equivalent to the Cave of gemcitabine or DMSO (0.058%). Tumor cell number was determined using luciferase signal as a surrogate with a standard curve. *p≤0.00003. N=3, with 5 independent measurements across the transwell from each replicate. (B) Cells were grown in 3D static culture for four days and then dosed for 3 days with 5.31 μM gemcitabine, the dose equivalent to the Cave of gemcitabine or DMSO (0.058%). Media and vehicle or drug was replenished every other day. Tumor cell number was determined using luciferase signal as a surrogate for cell number with a standard curve. N=3, with 5 independent measurements across the transwell from each replicate.