Fig. 3.

Significantly increased or decreased KEGG orthologies in RRMS associated with butyrate or propionate metabolism. (A–G) Relative abundance of the KEGG orthologies (KOs) involved in the pathway of butyrate metabolism (A–C) or propionate metabolism (A and D–G) that were significantly decreased in RRMS compared with HC. (H) Relative abundance of the KO involved in the pathway of propionate metabolism that was significantly increased in RRMS compared with HC. Each box plot represents median, interquartile range, minimum, and maximum values. *P < 0.05, **P < 0.01, ***P < 0.001 based on Wilcoxon rank sum test with the Benjamini–Hochberg method for multiple group comparisons.