Table 1.
All patients | Signs & symptoms | Incidentaloma | Surveillance | |||||
---|---|---|---|---|---|---|---|---|
PPGL | No PPGL | PPGL | No PPGL | PPGL | No PPGL | PPGL | No PPGL | |
N | 243 | 1774 | 89 | 1170 | 88 | 387 | 66 | 217 |
BMI (kg/m2) | 25* | 28 | 25* | 28 | 25* | 29 | 25* | 27 |
Heart rate (b/min) | 79* | 72 | 81* | 72 | 78* | 73 | 77* | 70 |
Pallor (%) | 26* | 13 | 37* | 15 | 21* | 10 | 18* | 7 |
Sweating (%) | 46* | 28 | 55* | 30 | 47* | 25 | 32* | 21 |
Palpitations (%) | 46* | 36 | 65* | 44 | 46* | 22 | 21 | 19 |
Tremor (%) | 25* | 15 | 33* | 18 | 21* | 8 | 18* | 6 |
Nausea /vomiting (%) | 21* | 11 | 26* | 12 | 18 | 11 | 20* | 10 |
Symptom score ≥3** | 42 | 18 | 56 | 21 | 40 | 13 | 28 | 1 |
Hypertension (%) | 83 | 85 | 95 | 93 | 80 | 78 | 71 | 58 |
Headaches (%) | 38 | 39 | 46 | 45 | 39 | 29 | 27 | 25 |
Weakness (%) | 42* | 35 | 51* | 36 | 34 | 32 | 42 | 32 |
Panic/anxiety (%) | 25 | 25 | 37 | 32 | 19 | 14 | 15* | 7 |
Flushing (%) | 20 | 23 | 21 | 27 | 23 | 17 | 14 | 14 |
Constipation (%) | 14* | 9 | 17* | 9 | 10 | 9 | 14 | 7 |
The full study cohort of the PMT study (Prospective Monoamine-Producing Tumor study)y (modified from [18]).
PPGL, Phaeochromocytoma or paraganglioma
significant differences between patients with and without PPGL;
symptom score: one point for each sign: BMI < 25 kg/m2, heart rate ≥85 beats/min, pallor, sweating, palpitations, tremor and nausea; a negative point for obesity;