Table 2.
Severity of Illness and Clinical Outcomes in Patients Who Did Receive Laxatives (LAX-48) or Did Not Receive Laxatives (NO-LAX-48) Within 48 Hours Prior to Clostridiodes difficile Infection Diagnosis
| LAX-48 (n = 65) | NO-LAX-48 (n = 144) | P | |||
|---|---|---|---|---|---|
| Outcomes | na | % | na | % | |
| Severe CDI by IDSA-SHEA [6] | 43 | 66.2 | 81 | 56.3 | .224 |
| Severe CDI by ESCMID [12] | 40 | 61.5 | 87 | 60.4 | 1.000 |
| Severe CDI by Zar et al [13] | 33 | 50.8 | 67 | 46.5 | .654 |
| Severe CDI by Belmares et al [14] | 8 | 12.3 | 22 | 15.3 | .673 |
| Composite of severe attributable outcomes: ICU admission, colectomy, or death within 40 days of diagnosis | 7 | 10.8 | 13 | 9.0 | .800 |
| Death within 40 days | 3 | 4.6 | 12 | 8.3 | .401 |
| CDI contributing or primary cause | 1 | 1.5 | 4 | 2.8 | .659 |
| ICU stay within 40 days | 11 | 16.9 | 26 | 18.1 | 1.000 |
| CDI contributing or primary cause | 7 | 10.8 | 13 | 9.0 | .744 |
| Colectomy | 1 | 1.5 | 1 | 0.7 | .526 |
| CDI recurrence within 40 days | 2 | 3.1 | 8 | 5.6 | .728 |
| Median (IQR) length of hospital admission after CDI diagnosis, days | 8 (4–16) | 5 (3–11) | .031 | ||
| Median (IQR) days to resolution of diarrhea | 8 (3–15) (n = 52) | 5 (3–12) (n = 117) | .074 | ||
Abbreviations: CDI, Clostridiodes difficile infection; ESCMID, European Society of Microbiology and Infectious Diseases; ICU, intensive care unit; IDSA, Infectious Diseases Society of America; IQR, interquartile range; SHEA, Society for Healthcare Epidemiology of America.
aUnless otherwise noted in parentheses for variables where not all patients had data obtained.