Figure 2.

CVac-phase parasite densities for all study arms. The estimated mean parasites/mL by qRT-PCR are shown for the combined pilot phase PQ/CQ arm (blue line), main phase PQ/CQ Arm (orange line), CQ arm (black line), and drug control arm (green line) following the first, second, and third PfSPZ± mosquito bite exposures. Time is shown relative to each PfSPZ± mosquito bite exposure, which were spaced 28 days apart. The cumulative number of subjects positive in each arm by thick blood smear and/or qRT-PCR over eligible subjects during that CVac are shown for each corresponding CVac phase. Abbreviations: -, noninfectious mosquito bites; +, infectious mosquito bites; CQ, chloroquine; CVac, chemoprophylaxis vaccination with sporozoites; Pf, Plasmodium falciparum; PQ, primaquine; qRT-PCR, qualitative real-time polymerase chain reaction; SPZ, sporozoites.