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. 2020 Sep 11;10:14954. doi: 10.1038/s41598-020-70890-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Candidate genes revealed by the modifier screen. (A) Graphic representation of a PANTHER4.0-driven gene ontology (GO) enrichment analysis of Alk modifying loci. (B) String analysis of the Alk modifier network. For visualization purposes, the line thickness represents the strength of support for an interaction within the network. Suppressors are shown in green; other modifiers are depicted in red. Details of the individual alleles tested are found in Table S1B.