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. 2020 Sep 11;10:14954. doi: 10.1038/s41598-020-70890-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ectopic wnd expression attenuates Alk-induced, JNK-mediated cell competition. (A–E) Eyes of adult female flies expressing the indicated transgene(s) under the control of the binary Gal/UAS- system or the GMR promotor. n > 75, 100% penetrance. (F) Phenotypic rescue of a sevEP-Gal4 > UAS-Alk fly eye by one copy of Df(3L)H99, a deficiency for the pro-apoptotic genes hid, grim, and rpr. n > 40, 100% penetrance. Scale bar = 100 µm. (G–I’’) Eye discs from pupae (50 apf) expressing sevEP-driven UAS-YFP and the JNK activity reporter TRE-RFP. TRE-activity is not observed in controls (G-G’’) but upon ectopic Alk expression (H–H’’). (I–I’’) TRE-activity in sevEP-Gal4 > UAS-Alk, UAS-wnd/ + eye discs co-expressing Wnd and Alk.