Fig. 5. Association of DEPTH scores with drug response in cancer.

a Correlations between DEPTH scores and drug sensitivity (IC50 values) of 265 compounds in cancer cell lines. The names of compounds with |ρ | > 0.3 are shown. b Comparison of DEPTH scores between the drug-responsive group and the non-responsive group in TCGA pan-cancer. c Comparison of DEPTH scores between the AML patients with MRD at the end of the second course of induction therapy and those without MRD, and the correlation between DEPTH scores and the MRD percentages after 8 days of remission induction therapy in the ALL phase II patients, using the TARGET datasets. AML, acute myeloid leukemia. ALL, acute lymphoblastic leukemia. MRD, minimal residual disease. d DEPTH scores are significantly higher in the cancer patients with better drug response than in those with worse drug response, as shown in three GEO datasets (GSE1379⁵³, GSE107850⁵⁴, and GSE123728⁵⁵).