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. 2020 Sep 11;11:4571. doi: 10.1038/s41467-020-18405-9

Fig. 3. Pre-symptomatic VX-765 treatment does not alter APP expression in J20 mice.

Fig. 3

a hAPP mRNA levels in the hippocampus at 4-week (n = 6 mice per group), 12-week (n = 3 mice per group) and 20-week (n = 4 mice per group) WO. b hAPP western blot and c quantification in the hippocampus at 4-week (n = 7 J20 + veh, 6 J20 + VX) and 20-week (n = 7 mice per group) WO using the human specific 6E10 antibody. Data in (a) and (c) represents mean and s.e.m.