Fig. 1.

Genome organization and structure of SARS-CoV-2. a SARS-CoV-2 genome contains ORF 1a/b (yellow and violet box respectively) which encodes genes like PL-pro, 3CL-pro, RNA- dependent RNA polymerase, helicase and endonuclease. The green box represents the size (in base pair) of spike protein, membrane protein and nucleocapsid protein. b Illustrates the SARS-CoV-2 structure, function of different membrane proteins and the mechanism of spike-receptor binding to ACE-2 receptor of host. CTD, carboxy-terminal domain; NTD, N-terminal domain; PL-pro, papain-like protease; 3CL-pro, 3CL-protease; RdRp, RNA- dependent RNA polymerase