Hypothesized cartoon of vein wall responses post thrombosis, in the sub-acute to late time points (after 8 days in mice, 14 days in humans). Note that the plasmin – MMP axis, and the endothelin-TGFb, and CCR7 via endothelial to mesenchymal transformation may all play a role, but at different stages of the resolving thrombus-vein wall integration Leukocytes are critical for driving these processes, including early PMN influx, followed later by monocyte/macrophages via CCR2 and CXCR2 chemokine receptors. Note that the arrows point to the ultimate process of collagen deposition and fibrosis. + = positive feedback loops; - = inhibition;