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Intrinsic and extrinsic factors in molecular signaling. Within the tumor microenvironment, intrinsic signaling occurs within the cancer cell whereas extrinsic activities are external to the cancer cell but can regulate the activity of intrinsic signals, for example, by interacting with receptors exposed on the plasma membrane or by uptake into the cancer cell and interacting internally with other factors present in the cancer cell. ECM = extracellular matrix
