Table 2:
Risk of preterm and term ischemic placental disease and its components in IVF compared with non-IVF pregnancies
| Cohort at risk for preterm IPD n = 69,084 | Cohort at risk for term IPD n = 60,797 | |||
|---|---|---|---|---|
| Outcome | IVF n=3763 | Non-IVF n=65321 | IVF n=2536 | Non-IVF n=58281 |
| SGA <10th percentile | ||||
| IPD/IUFD | 580 (15.4) | 2434 (3.7) | 478 (18.8) | 6339 (10.9) |
| RR (95% CI) | 4.1 (3.8–4.5) | 1.0 | 1.7 (1.6–1.9) | 1.0 |
| aRR (95% CI) | 4.0 (3.7–4.4)a | 1.0 | 1.7 (1.6–1.9)a | 1.0 |
| Preeclampsia | 273 (7.3) | 1160 (1.8) | 96 (3.8) | 1194 (2.0) |
| RR (95% CI) | 4.1 (3.6–4.6) | 1.0 | 1.8 (1.5–2.3) | 1.0 |
| aRR (95% CI) | 3.5 (3.1–4.1)a | 1.0 | 1.5 (1.2–1.9)a | 1.0 |
| Abruption | 97 (2.6) | 509 (0.8) | 26 (1.0) | 334 (0.6) |
| RR (95% CI) | 3.3 (2.7–4.1) | 1.0 | 1.8 (1.2–2.7) | 1.0 |
| aRR (95% CI) | 3.7 (2.9–4.6)b | 1.0 | 1.6 (1.05–2.4)b | 1.0 |
| SGA | 342 (9.1) | 1134 (1.7) | 385 (15.2) | 5073 (8.7) |
| RR (95% CI) | 5.2 (4.7–5.9) | 1.0 | 1.7 (1.6–1.9) | 1.0 |
| aRR (95% CI) | 5.2 (4.5–5.9)a | 1.0 | 1.8 (1.7–2.0)a | 1.0 |
| SGA <3rd percentile | ||||
| IPD/IUFD | 417 (11.1) | 1863 (2.9) | 234 (9.2) | 2589 (4.4) |
| RR (95% CI) | 3.9 (3.5–4.3) | 1.0 | 2.1 (1.8–2.4) | 1.0 |
| aRR (95% CI) | 4.0 (3.6–4.5)b | 1.0 | 1.9 (1.7–2.2)a | 1.0 |
| SGA | 89 (2.4) | 268 (0.4) | 119 (4.7) | 1165 (2.0) |
| RR (95% CI) | 5.8 (4.5–7.3) | 1.0 | 2.3 (2.0–2.8) | 1.0 |
| aRR (95% CI) | 6.3 (4.9–8.1)b | 1.0 | 2.5 (2.0–3.0)a | 1.0 |
Data presented as n (%), crude risk ratio (RR), adjusted risk ratio (aRR) and 95% confidence interval (CI)
IPD, ischemic placental disease; IUFD, intrauterine fetal demise; SGA, small for gestational age
a
Adjusted for maternal age, parity
b
Adjusted for maternal age