Table 1:
Demographic and clinical characteristics of women with ovarian cancer from the Ovarian Cancer Association Consortium (OCAC) included in the survival analysis.
| Pre-diagnosis MHT use duration | ||||
|---|---|---|---|---|
| Overall1 | Never | <5 years | 5+ years | |
| N | 6419 | 3784 | 1183 | 1452 |
| Hormone therapy use (%) | ||||
| None | 3784 (58.9) | 3784 (100.0) | 0 (0.0) | 0 (0.0) |
| ET only | 909 (14.2) | 0 (0.0) | 379 (32.0) | 530 (36.5) |
| EPT only | 1188 (18.5) | 0 (0.0) | 561 (47.4) | 627 (43.2) |
| ET and EPT | 212 (3.3) | 0 (0.0) | 62 (5.2) | 150 (10.3) |
| Unknown +/− ET/EPT | 326 (5.1) | 0 (0.0) | 181 (15.3) | 145 (10.0) |
| Age at dx. (mean (SD)) | 62.67 (8.71) | 62.36 (9.33) | 60.78 (8.16) | 65.00 (6.75) |
| Education (%) | ||||
| Less than high school | 1135 (20.7) | 760 (23.7) | 177 (17.4) | 198 (15.9) |
| High school graduate | 1567 (28.6) | 948 (29.6) | 272 (26.7) | 347 (27.8) |
| Some college | 1325 (24.2) | 745 (23.2) | 265 (26.0) | 315 (25.3) |
| College graduate | 799 (14.6) | 400 (12.5) | 174 (17.1) | 225 (18.1) |
| Graduate school | 646 (11.8) | 353 (11.0) | 132 (12.9) | 161 (12.9) |
| Race / ethnicity (%) | ||||
| Non-Hispanic white | 5679 (88.5) | 3308 (87.4) | 1042 (88.1) | 1329 (91.5) |
| Hispanic white | 198 (3.1) | 126 (3.3) | 45 (3.8) | 27 (1.9) |
| Black | 101 (1.6) | 72 (1.9) | 15 (1.3) | 14 (1.0) |
| Asian | 249 (3.9) | 146 (3.9) | 51 (4.3) | 52 (3.6) |
| Other | 192 (3.0) | 132 (3.5) | 30 (2.5) | 30 (2.1) |
| Histotype (%) | ||||
| Low-grade serous | 245 (3.8) | 134 (3.5) | 47 (4.0) | 64 (4.4) |
| High-grade serous | 4393 (68.4) | 2504 (66.2) | 820 (69.3) | 1069 (73.6) |
| Mucinous | 373 (5.8) | 255 (6.7) | 65 (5.5) | 53 (3.7) |
| Endometrioid | 925 (14.4) | 552 (14.6) | 168 (14.2) | 205 (14.1) |
| Clear cell | 483 (7.5) | 339 (9.0) | 83 (7.0) | 61 (4.2) |
| Stage (%) | ||||
| Local (FIGO I) | 947 (14.8) | 616 (16.3) | 173 (14.6) | 158 (10.9) |
| Regional (FIGO II) | 1126 (17.5) | 684 (18.1) | 211 (17.8) | 231 (15.9) |
| Advanced (FIGO III/IV) | 4346 (67.7) | 2484 (65.6) | 799 (67.5) | 1063 (73.2) |
| BMI category (%) | ||||
| Underweight | 117 (2.0) | 71 (2.1) | 18 (1.6) | 28 (2.0) |
| Normal weight | 2684 (45.7) | 1424 (42.0) | 515 (45.9) | 745 (54.5) |
| Overweight | 1754 (29.9) | 1026 (30.3) | 339 (30.2) | 389 (28.5) |
| Obese | 1320 (22.5) | 866 (25.6) | 249 (22.2) | 205 (15.0) |
| Family2 cancer history (%) | ||||
| Breast cancer | 1098 (17.6) | 690 (18.9) | 195 (16.8) | 213 (15.0) |
| Ovarian cancer | 329 (5.3) | 203 (5.6) | 61 (5.3) | 65 (4.6) |
| Combined oral contraceptive use (%) | ||||
| Never | 3127 (49.2) | 2030 (54.2) | 451 (38.6) | 646 (44.9) |
| <1 year | 590 (9.3) | 313 (8.4) | 142 (12.1) | 135 (9.4) |
| 1 to <5 years | 1209 (19.0) | 659 (17.6) | 265 (22.7) | 285 (19.8) |
| 5 to <10 years | 773 (12.2) | 390 (10.4) | 176 (15.1) | 207 (14.4) |
| 10+ years | 656 (10.3) | 356 (9.5) | 135 (11.5) | 165 (11.5) |
| Parity (%) | ||||
| 0 births | 1223 (19.1) | 738 (19.6) | 232 (19.6) | 253 (17.4) |
| 1 birth | 858 (13.4) | 525 (13.9) | 157 (13.3) | 176 (12.1) |
| 2+ births | 4324 (67.5) | 2508 (66.5) | 794 (67.1) | 1022 (70.4) |
| Smoking (%) | ||||
| Never | 2910 (52.9) | 1803 (55.5) | 495 (48.8) | 612 (49.4) |
| Current | 700 (12.7) | 445 (13.7) | 126 (12.4) | 129 (10.4) |
| Former | 1891 (34.4) | 998 (30.7) | 394 (38.8) | 499 (40.2) |
1
The total N for certain variables reported does not total to 6,419 because of missing data. These included variables that were not confounders and thus not needed for covariate adjustment in final models, such as family history of cancer, education, and smoking.
2
First-degree family members, i.e. sister or mother.