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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Transl Res. 2020 May 17;225:82–94. doi: 10.1016/j.trsl.2020.05.003

Table 2:

Contraindications to systemic fibrinolysis

Absolute contraindications Relative contraindications
Active bleeding Recent bleeding
Ischemic stroke within 3 months Current use of anticoagulation
Prior intracranial hemorrhage Systolic BP >180 mmHg
Brain or spinal surgery within 1 month Diastolic BP >110 mmHg
Structural cerebrovascular disease or CNS neoplasm Traumatic or prolonged cardiopulmonary resuscitation
Suspected aortic dissection Ischemic stroke more than 3 months prior
Recent head trauma with fracture or brain injury Recent non-CNS surgery or invasive procedure
Abdominal surgery within 7 days Pericarditis or pericardial fluid
Pregnancy
Low body weight (<60 kg)
Age >75 years
Diabetic retinopathy