Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cancer Metastasis Rev. 2020 Sep;39(3):769–781. doi: 10.1007/s10555-020-09886-7

Figure 4:

Figure 4:

MDA-9/Syntenin interacts with a broad spectrum of protein partners and regulates diverse signaling cascades: Following interaction with FAK/SRC complex MDA-9/Syntenin regulates p38MAPK, ultimately regulating MMPs. MDA-9/Syntenin also regulates VEGFA and MMPs via regulating STAT3. MDA-9/Syntenin interacts with EGFR which deregulates the GSK3β/β-Catenin pathway. Also, it interacts with ILK complex regulating IGFBP2 mediated by HIF1α. In addition, MDA-9/Syntenin regulates the TGFβ pathway.