Schematic diagram of neural circuits for mechanical and chemical itch. +, - denote excitatory and inhibitory synapses, respectively. GRP, Gastrin Releasing Peptide; GRPR, Gastrin Releasing Peptide Receptor; LTMRs, Low-threshold mechanoreceptors; NK1R, Neurokinin 1 Receptor; NPRA, Natriuretic Peptide Receptor A; NPY, Neuropeptide Y; NPY1R, NPY1 receptor; SST, somatostatin; TLR5, Toll Like Receptor 5.