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. 2020 Sep 12;6:85. doi: 10.1038/s41420-020-00320-z

Fig. 7. A graphical model of the pyroptosis effects of various molecules on MCD keratocytes.

Fig. 7

CHST6 gene mutation and impairment of the autophagy signaling pathway induce excessive production of non-sulfated KS. Non-sulfated KS aggregations form clinically phenotypic features, depositing in the corneal stromal extracellular matrix and causing focal patchy white opacity. A chronic overload of non-sulfated KS aggregations, as a DAMP, triggers the NLRP3 inflammasome and keratocytes undergo pyroptosis via the intrinsic pathway. The caspase-1-mediated pyroptosis signaling pathway might be a latent therapeutic target for treatment of MCD.