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. 2020 Sep 3;5(17):e136215. doi: 10.1172/jci.insight.136215

Figure 1. Lipodystrophic mice are predisposed to hepatic metastasis.

Figure 1

(A–D) Two-month-old FF and Con mice were injected with Bo1 cells via left ventricular chamber, and 12 days later tumor burden was analyzed. (A) In vivo BLI image; (B) ex vivo image of liver, bone, lung, and kidney; (C) gross appearance of Con and FF liver; and (D) quantification of tumor burden in liver, bone, lung, and kidney of Con and FF mice. n = 8–13. ROI, region of interest. (E–H) Two-month-old PPAR ADQ and Con mice were injected with Bo1 cells via left ventricular chamber, and 12 days later tumor burden was analyzed. (E) In vivo BLI image; (F) ex vivo image of liver, bone, lung, and kidney; (G) gross appearance of Con and FF liver 12 days after tumor injection; and (H) quantification of tumor burden in liver, bone, lung, and kidney of Con and FF mice. n = 7. Data are presented as mean ± SD. **P < 0.01, ***P < 0.001 as determined by unpaired 2-tailed t test.