Table 2.

Association between EDCs and single CpGs under different analytical conditions.

Input values/correction/transformation	Raw/No/No	Raw/No/Log	Raw/SVA/No	Raw/SVA/Log	Quartiles/SVA/No
TCS (triclosan)
Genomic inflation factor	1.40	1.56	1.24	1.31	1.05
CpGs at FDR < 0.05	327a	1156a	521a	898a	0
BPA (bisphenol A)
Genomic inflation factor	1.77	1.38	1.35	1.09	1.01
CpGs at FDR < 0.05	3383a	227a	757a	210a	0
BP-3 (benzophenone-3)
Genomic inflation factor	0.77	0.77	1.15	1.13	1.09
CpGs at FDR < 0.05	19a	13a	147a	95a	0
2,4-DCP (2,4-dichlorophenol)
Genomic inflation factor	1.06	1.21	1.14	1.18	1.06
CpGs at FDR < 0.05	101a	305a	198a	263a	0
Σphth.m (11 phthalate metabolites)b
Genomic inflation factor	0.89	0.91	1.12	1.11	1.10
CpGs at FDR<0.05	0	0	2	3	0

^aDriven by single point measurements (Supplementary File 1); ^bSee ‘Methods’ section for explanation on which phthalate measurements that are included.

CpG, DNA methylation loci; FDR, false discovery rate; SVA, surrogate variable analysis .