Table 2:
Thromboelastometry and thrombus area results
| Healthy control (n=23) | SCD (n = 5) | P value | |
|---|---|---|---|
| Age, median (range) | 29 (26–32) | 29 (26–32) | NA* |
| Gender (% male) | 80% | 80% | NA* |
| Thrombus area, low shear μm2 -median (range) | 6217 (4984 – 6832) | 7250 (5541 – 8971) | 0.001 |
| Thrombus area, high shear μm2 -median (range) | 13559 (11329 – 15005) | 11124 (10269 – 12907) | 0.08 |
| Intrinsic TEM - median (range) | |||
| CT | 149 (146 – 174) | 163 (116 – 200) | 0.73 |
| A5 | 42 (35 – 48) | 52 (30 – 60) | 0.04 |
| A30 | 63 (55 – 63) | 67 (52 – 74) | 0.05 |
| CFT | 78 (68 – 123) | 55 (44 – 157) | 0.04 |
| MCF | 62 (54 – 64) | 67 (52 – 74) | 0.04 |
| MCF-t | 1875 (1322 – 2149) | 1441 (1200 – 1945) | 0.05 |
| Alpha angle | 76 (67 – 77) | 79 (63 – 81) | 0.04 |
| CFR | 76 (68 – 79) | 80 (63 – 82) | 0.05 |
| MCE | 171 (146 – 178) | 206 (108 – 281) | 0.05 |
| G | 8544 (7315 – 8914) | 10302 (5402 – 14060) | 0.05 |
| TPI | 68 (36 – 81) | 111 (21 – 192) | 0.05 |
| MAXV | 17 (10 – 20) | 22 (8 – 29) | 0.04 |
| MAXVt | 170 (158 – 203) | 197 (148 – 216) | 0.6 |
| AUC | 6135 (5379 – 6323) | 6689 (5159 – 7329) | 0.04 |
| Extrinsic TEM - median (range) | |||
| CT | 65 (50 – 66) | 102 (89 – 113) | 0.00 |
| A5 | 43 (34 – 46) | 52 (32 – 61) | 0.04 |
| A30 | 64 (56 – 66) | 66 (54 – 72) | 0.4 |
| CFT | 96 (78 – 149) | 55 (46 – 147) | 0.02 |
| MCF | 65 (52 – 66) | 66 (54 – 72) | 0.19 |
| MCF-t | 1934 (1636 – 2197) | 1438 (952 – 1878) | 0.00 |
| Alpha angle | 71 (62 – 75) | 79 (63 – 80) | 0.02 |
| CFR | 75 (68 – 77) | 80 (68 – 81) | 0.02 |
| MCE | 180 (124 – 195) | 198 (117 – 254) | 0.23 |
| G | 9013 (6169 – 9756) | 9925 (5863 – 12706) | 0.29 |
| TPI | 62 (25 – 75) | 112 (24 – 165) | 0.05 |
| MAXV | 15 (10 – 17) | 24 (10 – 27) | 0.02 |
| MAXVt | 117 (84 – 151) | 127 (121 – 155) | 0.09 |
| AUC | 6398 (5182 – 6691) | 6593 (5381 – 7123) | 0.52 |
*
P values not calculated because participants were age and gender matched to controls