Table 1. Deaths and disease recurrence following cystectomy.
(Per-protocol population)
| Characteristic | Robotic Cystectomy (N=150) n (%) |
Open Cystectomy (N=152) n (%) |
P |
|---|---|---|---|
| Total events for OS | 38 (25.3) | 43 (28.3) | 0.432a |
| Death from bladder cancer | 28 (18.7) | 32 (21.3) | |
| Non-bladder cancer death | 10 (6.7) | 11 (7.2) | |
| Total events for PFS | 49 (32.7) | 50 (32.9) | 0.756a |
| Any recurrence | 39 (26.0) | 39 (26.3) | |
| Non-bladder cancer death | 10 (6.7) | 11 (7.2) | |
| Recurrence, alive at last contact | 11 (7.3) | 7 (4.6) | |
| Pure local recurrence: Total | 6 (4.0) | 4 (2.6) | 0.541b |
| Cystectomy bed1 | 6 (4.0) | 2 (1.3) | |
| Pelvic lymphadenectomy template | 0 | 1 | |
| Abdominal wall/Port site | 0 | 1 | |
| Distant recurrence (with or without local): Total | 33 (22.0) | 35 (23.0) | 0.605b |
| Lung | 8 | 10 | |
| Liver | 6 | 7 | |
| Bone | 9 | 10 | |
| Extrapelvic lymph nodes | 9 | 9 | |
| Peritoneal carcinomatosis | 2 | 1 | |
| Adrenal | 2 | 1 | |
| Colon | - | 3 | |
| Small Intestine | 1 | - | |
| Kidney | 1 | - | |
| Brain | - | 1 | |
| Not specified | 4 | ||
| Secondary Urothelial Ca: Total | 1 (0.6) | 3 (2.0) | |
| Upper urinary tract | 1 | 2 | |
| Urethra | 0 | 1 | |
| Censored observations: Total | 101 (67.3) | 102 (67.1) | |
| Censored within first 2 years | 10 (6.7) | 14 (9.2) | |
| Under follow-up | 9 | 8 | |
| Lost-to-follow-up | 1 | 6 | |
a
P value from log-rank test for OS and for PFS.
b
P value from Gray’s test for local recurrence and for distant recurrence taking into account as competing risks the other site of recurrence and non-bladder cancer death.