Table 3.
Independent risk factors associated with no sustained virologic response
| Factor before treatment | Responder (n = 84) | Non-responder (n = 21) | Univariate analysis p value | OR (95% CI)a | Multivariate analysis p value |
|---|---|---|---|---|---|
| Age, yr | 50.3 ± 9.4 | 52.7 ± 9.1 | 0.286 | ||
| Sex, male | 39 (46.4) | 10 (47.6) | 0.922 | ||
| Genotype 1 | 18 (21.4) | 15 (71.4) | < 0.001 | 8.72 (2.27–33.54) | 0.002 |
| BMI, kg/m2 | 24.3 ± 3.0 | 26.0 ± 4.9 | 0.050 | ||
| Waist circumference, cm | 85.6 ± 9.1 | 90.8 ± 13.1 | 0.036 | 1.09 (1.02–1.18) | 0.016 |
| Diabetes mellitus | 8 (9.5) | 5 (23.8) | 0.075 | ||
| Sun exposure, hr/day | 2.5 ± 2.1 | 2.8 ± 2.5 | 0.487 | ||
| Total bilirubin, mg/dL | 0.6 ± 0.3 | 0.8 ± 0.4 | 0.013 | ||
| Albumin, g/dL | 4.4 ± 0.3 | 4.2 ± 0.3 | 0.087 | ||
| 25(OH) vitamin D3, ng/mLa | 15.9 ± 7.7 | 15.7 ± 10.4 | 0.922 | ||
| < 10 | 16 (20.3) | 5 (26.3) | 0.332 | ||
| 10–20 | 33 (53.2) | 11 (57.9) | |||
| ≥ 20 | 17 (26.6) | 3 (15.8) | |||
| Vitamin D supplementation | 49 (58.3) | 9 (42.9) | 0.202 | ||
| AFP, ng/mL | 8.3 ± 14.1 | 14.4 ± 14.7 | 0.081 | ||
| HCV PCR > 600,000 IU/mL | 44 (53.0) | 18 (85.7) | 0.031 | 6.27 (1.18–33.52) | 0.031 |
| Cirrhosis | 7 (8.3) | 3 (14.3) | 0.415 |
Values are presented as mean ± SD or number (%).
OR, odds ratio; CI, confidence interval; BMI, body mass index; AFP, alpha fetoprotein; HCV PCR, hepatitis C virus polymerase chain reaction.
a
Age, sex-adjusted odds ratio.