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. 2020 Aug 31;8:712. doi: 10.3389/fcell.2020.00712

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Copyright © 2020 Zhong, Fu, Li, Chen, Wang, Gao, Zhang, Cheng, Zhang, Li, Zhang, Qian, Shu, Chai and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Citicoline increases the MMP of HEI-OC-1 cells after neomycin exposure. (A) The three groups of HEI-OC-1 cells were labeled using the TMRE staining kit. (B) Flow cytometry data confirmed the results in (A). (C) Quantification of the flow cytometry results in (B). The TMRE intensity was significantly decreased after neomycin exposure compared to the undamaged controls. In addition, the TMRE intensity was significantly increased in the citicoline treatment group compared to the neomycin-only group. Data are shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. Scale bars = 20 μm.