Effect of Cur and DOX on biochemical and biometric parameters. (A) Body weights (BW); (B) heart weights (HW); (C) HW-to-BW ratio; (D) serum CK release; (E) serum AST release; (F) serum LDH content; (G) SOD activity; and (H) MDA content. Mean ± SD, n=14 (panels A, B, C) or 9–10 (panels D, E, F, G, H) per group. *, P<0.05 between the indicated groups. Con, Control group; DOX, DOX group; DOX-Cur [100], DOX with Cur treatment at 100 mg·kg−1; DOX-Cur [200], DOX with Cur treatment at 200 mg·kg−1; DOX-Cur [400], DOX with Cur treatment at 400 mg·kg−1; Con-Cur [400], 400 mg·kg−1 Cur treatment in control group; BW, body weight; HW, heart weight; CK, creatine kinase; AST, aspartate amino transferase; LDH, lactate dehydrogenase; SOD, superoxide dismutase; MDA, malondialdehyde.