Figure 2.
Effect of Cur on apoptosis and pyroptosis protein markers in DOX-treated mice. (A) Representative gel blots of Bcl-2 and Bax proteins using specific antibodies (GAPDH as loading control); (B) Bax; (C) Bcl-2; (D) Bax-to-Bcl-2 ratio; (E) representative gel blots of NLRP3, Caspase-1, IL-18 and IL-1β proteins using specific antibodies expression (GAPDH as loading control); (F) NLRP3; (G) Caspase-1; (H) IL-18; and (I) IL-1β. Mean ± SD, n=3–4 per group, *, P<0.05 between the indicated groups. Bcl-2, B-cell lymphoma-2; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Bax, Bcl-2 associated X protein; NLRP3, NLR family pyrin domain containing 3; IL-18, interleukin-18; IL-1β, interleukin-1β.