The overall architecture of the proposed system that compares the CVD/stroke risk stratification performed using the CVRCML and the 13 types of statistically derived CVRCStat. CVRCML, ML-based cardiovascular risk calculator; CVRCStat, 13 types of different statistically derived cardiovascular risk calculators; CVD, cardiovascular disease; CUSIP, carotid ultrasound image-based phenotypes; EEGS, event-equivalence gold standard; AUC, area under the curve.