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Two-stage system for IVA design and performance evaluation. Stage 1: integrated vascular age computation and stage 2: risk stratification and performance evaluation. CCVRF, conventional cardiovascular risk factors; CUSIP, carotid ultrasound image-based phenotypes, IVA, integrated vascular age; EEGS, event-equivalence gold standard; PE, performance evaluation; AUC, area-under-the-curve.
