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. 2020 Aug;10(4):738–751. doi: 10.21037/cdt-20-407

Figure 7.

Figure 7

Schematic diagram of miR-181b hypermethylation in patients with coronary artery disease and miR-181b-PIAS1 axis in macrophage polarization. Hypermethylation of miR-181b promoter in circulating monocytes of patients with coronary artery disease (CAD) results in lower expression of miR-181b as compared with healthy individuals. Decreased miR-181b inhibits the expression of KLF4 via restoring PIAS1 and promoting KLF4 SUMOylation, eventually facilitating M1 polarization and alleviating M2 polarization.