FIGURE 10.

Lack of Dp427 reduces the number of EdU⁺ proliferating cells in P5 and P10 mdx mice compared to wild type. On the left side, representative images of EdU⁺ cell (green) distribution in the anterior (A), central (B), and posterior (C) regions of the retina of P0, P5, and P10 wild type (wt) and mdx mice; nuclei are stained in blue (Hoechst). At P0–P5, proliferating cells mostly occupy the neuroblastic cell layer. On the right side, comparative analyses of the number of EdU⁺ proliferating cells/region of interest (ROI) between wt and mdx age-matched mice (top graphs) and across post-natal days within the same genotype (bottom graphs). Data are analyzed by either two-way ANOVA test Sidak post hoc (top graphs) or one-way ANOVA test Tukey post hoc (bottom graphs) and represented as the mean ± SEM. ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001 (mdx vs. wt; P5, P10 vs. P0); ^#p ≤ 0.05, ^##p ≤ 0.01, ^###p ≤ 0.001 (P10 vs. P5). n = 3–6 independent experiments. Scale bar: 100 μm.