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. 2020 Sep 4;18:342. doi: 10.1186/s12967-020-02492-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Consensus clustering of HCC molecular subgroups based on hypoxia-related DEGs. a Cumulative distribution function (CDF) curve. b CDF Delta area curve, which indicates the relative change in the area under the CDF curve for each category number k compared with k-1. The horizontal axis represents the number k and the vertical axis represents the relative change in the area under the CDF curve. c The Item-Consensus Plot for k = 4. The vertical axis represents item-consensus values and each bar represents each sample. d The heatmap corresponding to the consensus matrix for k = 4 obtained by applying consensus clustering. The rows and columns of the matrix represent samples. The values of the consistency matrix are shown in white to dark blue from 0 to 1, which represent the degree of consensus. e The heatmap of 397 hypoxia-related genes in 4 clusters