Table 1.

Prognostic biomarkers in chronic lymphocytic leukemia

Category	Prognostic biomarkers
Serum markers	Thymidine kinase, beta2-microglobulin, lactic dehydrogenase, lymphocyte doubling time, autocrine interleukin-6, copper, free light chains, lipoprotein lipase, c-reaction protein, BAFF, TACI, APRIL, BCMA, EZH2
Immunophenotypic markers	CD38, ZAP70, CD49d, CD26, CD54, CD44, CD52, CD69, CD25, CD5, CD95, CD39, CD11c, CD36, CD150
IGHV mutation status	M-CLL, U-CLL
Chromosome aberrations	Del13q, del11q, tri12, del17p, del16q, del19p21, del10q23, total or partial trisomies of chromosomes 3, 8, 18, 19 and duplications in 2p24
Gene mutations	TP53, ATM, NOTCH1, BIRC3, MYD88, SF3B1, FBXWY, POT1, CHD2, RPS15, IKZF3, ZNF292, ZMYM3, ARID1A, PRPN11, COBLL1, LPL, ZAP70
Non-coding RNA and others	MiR-15a, miR-16-1, miR-155, miR-29a, miR-29b, miR-34a, miR-125a, miR-155, miR-181b, I-tRF-GlyCCC